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KPV (Lys-Pro-Val Tripeptide)

KPV is a synthetic tripeptide composed of lysine (K), proline (P), and valine (V) — derived from the C-terminal fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). It is studied in laboratory and rodent models for its interactions with NF-kB inflammatory signaling and the melanocortin-1 receptor (MC1R).

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Product Specifications

  • Sequence: 3 amino acids (Lys-Pro-Val)
  • Origin: alpha-MSH C-terminus
  • Form: Lyophilized 10mg
  • Documentation available
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Research use only. Not for human or animal use.

Research Summary

  • KPV has been studied in rodent models of colitis (DSS- and TNBS-induced), with reported reductions in inflammatory markers.
  • Mechanistic research focuses on NF-kB pathway modulation and PepT1-mediated cellular uptake.
  • Wound-healing studies have examined KPV via melanocortin-1 receptor (MC1R) signaling in cell and animal models.
  • Compared to full alpha-MSH, KPV does not produce pigmentation effects — making it useful for isolating anti-inflammatory pathways in research.

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Important Disclaimer

This page is for educational and informational purposes only. This product is a research chemical sold for laboratory use only. Not intended for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider. These statements have not been evaluated by the FDA.